NOD1 expression is increased in the adipose tissue of women with gestational diabetes

Abstract

Maternal peripheral insulin resistance and increased inflammation are two features of pregnancies, complicated by gestational diabetes mellitus (GDM). The nucleotide-binding oligomerisation domain (NOD) intracellular molecules recognise a wide range of microbial products, aswell as other intracellular danger signals, thereby initiating inflammation through activation of nuclear factor κB (NFκB). The aimof this study was to determinewhether levels of NOD1 and NOD2 are increased in adipose tissue of womenwith GDM. The effect of NOD1 and NOD2 activation on inflammation and the insulin signalling pathwaywas also assessed. NOD1, but not NOD2, expression was higher in omental and subcutaneous adip..